Recent advances in the management of mucormycosis: from bench to bedside.

Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside

Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics...

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

Rett syndrome from bench to bedside: recent advances

Successful Management of Rhinocerebral Mucormycosis in a Child with Uncontrolled Diabetes Mellitus and Recent Blindness: A Case Report

Background and Aim: Mucormycosis is an aggressive and life-threating fungal infection that affects patients with uncontrolled diabetes mellitus (DM) or compromised immune system. The most common symptom of rhinocerebral mucormycosis is sinusitis, and if the infection spreads beyond the sinus, more severe symptoms such as blindness, seizure, and death may occur. Case Presentation: We descri...

Critical issues in nephrology.

Renal and electrolyte problems are common in patients in the ICU. Several advances that occurred in the recent past have been incorporated in the diagnosis and management of these disorders and were reviewed in this article. Unfortunately, many important questions remain unanswered, especially in the area of ARF, where new therapies are anxiously awaited to make the transition from bench to bed...